I think the best Hacker load would have to be my Ballista load. Unfortunately, it's pretty much a Win or Lose load. First of all, I'd recommend you only use it for PvP, mainly because for it to work you need luggables.
You need Logic Cannon 2.0, Insidious Code, Viral Accuracy Boost, Overclock, and the -50 something Viral Defense debuff. (also a lock, preferably the 1.0 because it lasts a lot longer)
First of all, you stack the LED black boxes for 15 points of Viral Damage, then you get another 15 stacked off of the Hacker Bomb Pets, and then you're set (plus bomb pets give you a nice accuracy boost).
Alright, first of all, although this sounds better used in duels, I'm sure someone isn't going to duel you because of your luggables as an unfair advantage, so in a 1 on 1 pvp situation, even though it's rare, you root someone with the 1.0 root. That gives you around 30-ish seconds. (Now remeber, this lock can be broken by damage so if anyone hits your target, or he is willing to sacrifice 256 health with an Assassin Mask, otherwise he's stuck. The only problem is if this doesn't hit, don't bother. Like I said, this load has a lot of weaknesses.)
Here's the problem. The only way to 1-shot your target is by doing exactly this. You pick your target, pop Viral Accuracy Boost, and then fling on the Viral Defense debuff. If this hits, you're in good shape since nearly all of your other moves should hit. Now the only disadvantage is if someone sees you pop Viral Accuracy Boost, they know you're going to use a debuff or lock because otherwise it'd be a waste to use it. So then you root somebody. Immediately after you need to do Insidious Code. IF THIS DOES NOT HIT, DO NOT CONTINUE. You *need* the -100 Viral Resistance otherwise again, this will not work. If Insidious code hits, you're probably going to get this to work.
Now, you pop Overlock, adding onto your 30 damage points another 25, giving you 55 extra damage points (which is a *poop* load) not to mention hopefully you're wearing Viral Damage/Accuracy % clothes to give you a few more. And you need to be statted of course.
Now finally you use a power Logic Cannon 2.0. If this hits, you will 1-shot your opponent every time unless they are an Upgrade Master, in which you can 2-3 shot them. Now like I said, let me list out the disadvantages.
#1, Luggables can be stolen, and you need them all.
#2, If your viral defense debuff misses, then you're probably screwed, but don't fret you might be able to get everything else off.
#3, if your Viral Resist debuff misses, like I said, those -100 points are crucial, and your 55 damage buff only lasts for so long. (2,3 shots)
#4, if your Logic Cannon 2.0 misses, then don't fret, use a Logic Blast or Barrage which can total up for a whopping 700-1000 damage with those debuffs on.
#5, This load SUCKS COMPLETELY IN IL. Unfortunately, your only IL options are to either run, or hopefully you can get a few hacks off with your viral accuracy boost. With your Howie/Ballista load, it's nearly impossible to load all the DoTs necessary in order to combat efficiently in IL. It's an EXCELLENT support class. The Sniper of the Hacker tree. Although you're supposed to lose 2v1, if you get interrupted at all, this load is completely pointless. Anyone who's smart enough, can either get your luggables, or load up Viral Defense and sit on block while you're hacking away.
How high does this hit? On an average clothed PvPer (like all MA accuracy gear for an MA) we're talking around the 2,800-3,200 damage range. The normal health for a level 50 is 2,600. So, auto-kill.
I got the delightful chance to catch Shuffleman in normal pvp gear with my lock while he was flagged sitting on a bench. I debuffed him all the way and got a whopping 12k damage (lol) on him. Granted the extra damage helped I'm sure. 
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nice to see the forum uses still have hackers on em.
<3
